The effects of zolpidem and zopiclone on daytime
sleepiness and psychomotor performance

by
Uchiumi M, Isawa S, Suzuki M,
Murasaki M.
Asuka Hospital,
371 Tsuruma,
Machida, 194-0004 Japan.
Nihon Shinkei Seishin Yakurigaku Zasshi 2000 Aug;20(3):123-30


ABSTRACT

Zolpidem (ZLP), which has selective affinity to the BZ1 (omega 1) receptor and a short half-life, is a novel hypnotic. The objective of this study is to compare the residual effects of standard clinical doses of ZLP and zopiclone (ZPC), a short-acting hypnotic marginally selective for the BZ1 (omega 1) receptor, given in a single dose on daytime sleepiness and psychomotor function. This study was carried out as a double-blind cross-over study with 10 mg ZLP, 7.5 mg ZPC and a placebo in 12 healthy male adults. In the multiple sleep latency test, sleep latency was not reduced but increased by ZLP and ZPC as well as the placebo when drug plasma levels had nearly reached the peak. Subjects administered ZLP were significantly more feeble, lethargic and antagonistic in mood rating scales than those administered ZPC. The incidence of severe behavioral side effects was higher in the case of ZLP than in the case of ZPC over the same period. Sleep latency the next morning was significantly shorter in the case of ZPC than in the case of ZLP or the placebo. The tapping test performed at the same time demonstrated that the number of taps was significantly less in the case of ZPC than in the case of ZLP or the placebo. The results of the present study suggest that ZLP acts more rapidly than ZPC. On the other hand, ZLP has less residual effect on sleepiness and psychomotor function the next morning.
Zolpidem
Insomnia
Sedatives
Alprazolam
Ambien drivers
Benzodiazepines
Zopiclone drivers
Zolpidem (Ambien)
Sleeping-pill hype?
Zopiclone: structure
Zolpidem v brotizolam
Eszopiclone (Lunesta)
Zopiclone: pharmacokinetics
Zolpidem (Ambien): structure
Zopiclone, sleep and insomnia
Zopiclone and desmethylzopiclone
Zolpidem (Ambien): prescribing information (PDF)
The new sleeping pills: Lunesta, Sonata and Rozerem
Zolpidem (Ambien), Zaleplon (Sonata), Zopiclone (Imovane)
Zolpidem (Ambien) and zopiclone (Imovane): weak antinociceptive effect


Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family