Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone
by
205 Woodland Court, Hermitage,
TN 37076, USA.
Lntdp@earthlink.net.
IDrugs. 2007 Mar;10(3):193-201.


ABSTRACT

Vilazodone is a combined selective serotonin reuptake inhibitor (SSRI) and a 5-HT(1A) receptor partial agonist that is being developed by Clinical Data Inc for the treatment of depression. In preclinical studies, vilazodone compared favorably to other antidepressants such as paroxetine and fluoxetine. Orally administered vilazodone inhibited ultrasonic vocalization in the rat after electrical foot shock (a model of anxiolytic activity). Yet, in the forced swimming test model of depression in rats, vilazodone administered intraperitoneally was active at 1 mg/kg but not at 3 or 10 mg/kg. During clinical trials, vilazodone completely abolished REM sleep for 8 h and demonstrated antidepressant efficacy that was equal to that of current antidepressant therapeutics. The author concludes that the success of vilazodone as an effective antidepressant agent will depend on whether the drug can produce a more rapid antidepressant effect than other SSRI agents, or if specific genetic markers of patients can be associated with clinical efficacy.
2009
5-HT1a
Vilazodone
Amineptine
Reboxetine
Nefazodone
Mirtazapine
Venlafaxine
21st Century
Antidepressants
Tranylcypromine
Atypical depression
Retarded depression
The monoamine hypothesis
Old and new antidepressants
Types of depression and mood-disorder
Are 'broad spectrum' antidepressants best?

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