Sildenafil citrate: lessons learned
from 3 years of clinical experience

by
Hatzichristou DG.
Department of Urology,
School of Medicine and Centre
for Sexual and Reproductive Health,
Aristotle University of Thessaloniki,
Thessalonki, Greece.
Int J Impot Res 2002 Feb;14 Suppl 1:S43-S52


ABSTRACT

In the 3 y since its initial approval, sildenafil has become the most widely used treatment for erectile dysfunction (ED) and has been prescribed to more than 13 million patients worldwide. Significant improvements in erectile function have been demonstrated in double-blind, placebo-controlled studies in diverse patient populations. A significant treatment effect has been shown with sildenafil in men with ED and a history of diabetes, cardiovascular disease, minor depression, spinal cord injury and multiple sclerosis. In addition, promising results have been shown in patients with treated prostate cancer, end-stage renal disease, Parkinson's disease and spina bifida and in multiple-organ transplant recipients. Postmarketing data of the use of sildenafil in clinical practice confirm the efficacy and safety found in clinical trials and high satisfaction with treatment. Public awareness of the common occurrence of ED and the high likelihood of a potentially favorable response to an oral treatment increased dramatically with the introduction of sildenafil. Physicians, however, are still not comfortable with ED management, which negatively affects pharmacotherapy response rates and patients' compliance to treatment. Continuing medical education seems mandatory to overcome existing problems in ED management.


SSRIs
Viagra
Oxytocin
Vardenafil
Yohimbine
Apomorphine
Testosterone
Phentolamine
Coolidge effect
Viagra: review
PT-141 ('Passion')
Viagra: mechanisms
The Viagra Revolution
Viagra: clinical efficacy
Semen as an antidepressant?
Yohimbine and sexual performance
The pharmacology of penile erection
Drugs to promote female sexual desire
Is sildenafil (Viagra) an antidepressant?
Viagra leaves fake aphrodisiacs flagging
Sildenafil (Viagra) and erectile dysfunction
Thrill-pills? Young men experiment with Viagra
Sildenafil (Viagra) for antidepressant-induced sexual dysfunction


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