Remission rates during treatment with venlafaxine
or selective serotonin reuptake inhibitors

by
Thase ME, Entsuah AR, Rudolph RL
University of Pittsburgh School of Medicine,
Western Psychiatric Institute and Clinic,
Pittsburgh, PA.
Br J Psychiatry 2001 Mar; 178(3):234-241


ABSTRACT

BACKGROUND: It had been suggested that the antidepressant venlafaxine, which inhibits reuptake of both serotonin and (at higher doses) noradrenaline, may result in better outcomes than treatment with selective serotonin reuptake inhibitors (SSRIs). AIMS: To compare remission rates during treatment with SSRIs or venlafaxine. METHOD: Data from eight comparable randomised, double-blind studies of major depressive disorder were pooled to compare remission rates (Hamilton Rating Scale for Depression score < /=7) during treatment with venlafaxine (n=851), SSRIs (fluoxetine, paroxetine, fluvoxamine; n=748) or placebo (four studies; n=446). RESULTS: Remission rates were: venlafaxine, 45% (382/851); SSRIs, 35% (260/748); placebo, 25% (110/446) (P: < 0.001; odds ratio for remission is 1.50 (1.3-1.9), favouring venlafaxine v. SSRIs). The difference between venlafaxine and the SSRIs was significant at week 2, whereas the difference between SSRIs and placebo reached significance at week 4. Results were not dependent on any one study or the definition of remission. CONCLUSIONS: Remission rates were significantly higher with venlafaxine than with an SSRI.
5-HT1
5-HT2
5-HT3
SSRIs
Serotonin
Dopamine
Duloxetine
Noradrenaline
Venlafaxine (Effexor)
Venlafaxine compared
Venlafaxine v fluoxetine
High-dose venlafaxine XL
Venlafaxine pharmacology
Venlafaxine plus bupropion
Venlafaxine and depression
Venlafaxine: pharmacokinetics etc
Venlafaxine versus paroxetine for OCD
Venlafaxine for depressive cocaine users
Venlafaxine for treatment-resistant depression
How effective are commonly prescribed antidepressants?


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