Venlafaxine dependence in a patient with a history of alcohol and amineptine misuse
Quaglio G, Schifano F, Lugoboni F.
Medical Service for Addictive Disorders,
Department of Internal Medicine,
University of Verona, Verona, Italy.
Addiction. 2008 Jul 10.


Background Venlafaxine is an inhibitor of neuronal serotonin and noradrenaline re-uptake and a weak inhibitor of dopamine re-uptake. There was no indication of problems of abuse/dependence during the clinical trials. Case description A 53-year-old client with a history of alcohol and amineptine misuse and a long history of recurrent depression, for which he was prescribed venlafaxine tablets. Over time, he increased the dosage to 50 tablets daily (3750 mg). Large venlafaxine dosages produced amphetamine-like effects, due possibly to the related increase in dopamine turnover. Once hospitalized for detoxification, the patient had a symptomatology which was consistent with a serotonergic discontinuation syndrome. Conclusions Physicians should be aware that patients with a history of drug and alcohol abuse might develop venlafaxine dependence.
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