A large open-label study of venlafaxine in depressed outpatients by community-based physicians
Joffe RT, Marshall AM, Lee DK
Department of Psychiatry,
McMaster University, Hamilton, Ontario, Canada.
J Clin Psychiatry 1998 Oct; 59(10):515-20


BACKGROUND: Studies to date suggest that venlafaxine is effective, well tolerated, and safe in a broad spectrum of patients. We examined the clinical utility and tolerability of venlafaxine in patients treated by community-based psychiatrists and family physicians in a naturalistic clinical setting. METHOD: Nineteen physicians each recruited 10 to 20 physicians to enroll 5 patients each maximum, diagnosed with DSM-IV major depression or dysthymia. The patients were at least moderately ill (Clinical Global Impressions) with a score of at least 32 on the Zung Self-Rating Depression Scale. After baseline clinical and laboratory assessments, each patient received 37.5 mg of venlafaxine b.i.d., with adjustments possible at the 5 visits during the next 8 weeks. RESULTS: Of the 880 patients at baseline, 682 completed the 8-week study. The daily doses of venlafaxine ranged between 18.75 mg and 375 mg, with 80% receiving between 75 and 150 mg/day by 8 weeks. The intent-to-treat analysis revealed that at 8 weeks, 62% (522 of 843) of patients were either much or very much improved. Nausea was the most frequent side effect, followed by somnolence, headache, and dry mouth. CONCLUSION: Venlafaxine has good clinical utility and tolerability in a community-based sample of a broad spectrum of depressed outpatients.
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Venlafaxine pharmacology
Venlafaxine for dysthymia
Venlafaxine for depression
Venlafaxine plus bupropion
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Venlafaxine for treatment-resistant depression
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Depression treated with different formulations of venlafaxine
February 2008: FDA licenses antidepressant desvenlafaxine (Pristiq)

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