Chipping away at complex behavior: transcriptome/phenotype
correlations in the mouse brain

by
Carter TA, Del Rio JA, Greenhall JA,
Latronica ML, Lockhart DJ, Barlow C.
The Salk Institute for Biological Studies,
Laboratory of Genetics, 10010 North Torrey Pines Road,
La Jolla, CA 92037, USA.
Physiol Behav 2001 Aug;73(5):849-57


ABSTRACT

Highly parallel gene expression profiling has the potential to provide new insight into the molecular mechanisms of complex brain diseases and behavioral traits. We review how gene expression profiling in various brain regions of inbred mouse strains has been used to identify genes that may contribute to strain-specific phenotypes. New data, which demonstrate the use of gene expression profiling in combination with behavioral testing to identify candidate genes involved in mediating variation in running wheel activity, are also presented. These and other studies suggest that a combination of gene expression profiling and more traditional genetic approaches, such as quantitative trait locus analysis, can be used to identify genes responsible for specific neurobehavioral phenotypes.
21st century
RNA silencing
Antidepressants
Transcriptomics
Pharmacogenetics
Pharmacogenomics
Antidepressants and the genome


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