A double-blind study of tranylcypromine
treatment of major anergic depression

by
Himmelhoch JM, Fuchs CZ, Symons BJ
J Nerv Ment Dis 1982 Oct;170(10):628-34


ABSTRACT

Fifty-nine anergically depressed patients were randomly assigned to 6 weeks of double-blind treatment with either tranylcypromine or placebo. Anergic major depression most typically occurs in primary bipolar and in pseudounipolar affective illnesses. We hypothesized that tranylcypromine would be a highly effective and rapid treatment for depressions of this type. Results of repeated measures analyses of variance showed superiority of active drug over placebo by the end of the first week, and this improvement increased in significance at each successive visit. Improvement on tranylcypromine after week 1 was greater than that on placebo after week 6. Analysis of covariance of week 6 scores (corrected for week 0 scores) showed significantly greater improvement for tranylcypromine patients on all measures of depressive symptomatology. Tranylcypromine is a rapid, relatively safe, and dramatically effective treatment for anergic depression. Since 24 of 29 of the bipolar subjects had previously failed to respond to tricyclics and since bipolar depression is usually anergic, tranylcypromine should be compared to imipramine to determine the antidepressant of choice for manic-depressive illness.
TCAs
MAO
MAOIs
TV3326
Dopamine
Bupropion
Anhedonia
Amineptine
Nomifensine
Hypersomnia
Noradrenaline
Tranylcypromine
MAOI interactions
Retarded depression
Phenelzine v imipramine
Tranycypromine: structure
Tranycypromine v imipramine
Tranylcypromine v moclobemide
Tranylcypromine, sleep and anergic bipolar depression
High-dose tranylcypromine (Parnate) for refractory depression


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