The treatment of Tourette's syndrome: current opinions
by
Muller-Vahl KR.
Department of Clinical Psychiatry and Psychotherapy,
Medical School Hannover,
Carl-Neuberg-Str. 1, D-30625 Hannover, Germany.
mueller-vahl.kirsten@mh-hannover.de
Expert Opin Pharmacother 2002 Jul;3(7):899-914


ABSTRACT

Correct education of the patient is one of the most important aspects in the treatment of Tourette's syndrome. Pharmacotherapy is often unsatisfactory and therefore should be limited to those patients who are significantly impaired. Therapy must be individualised and the most troublesome symptom should be targeted first. In the treatment of tics, dopamine receptor blocking agents are currently the most effective drugs. It is currently unknown whether classic neuroleptics, such as pimozide, selective dopamine receptor antagonists, such as sulpiride, or newer atypical antipsychotics, such as risperidone, have the best adverse effect profile. Tiapride can be used as an alternative, particularly in children. Selective serotonin-re-uptake inhibitors are recommended for the treatment of obsessive-compulsive behaviour. In children suffering from attention deficit hyperactivity disorder, psychostimulants, such as methylphenidate, are the treatment of choice. Recent studies have provided increasing evidence that stimulants do not cause a significant increase in tics in the majority of patients.
D1
Reward
Structure
Selegiline
Roxindole
Dopamine
Amineptine
Pramipexole
Bromocriptine
Methylphenidate
Tranylcypromine
Drugs and reward
Dopamine and sex
The dopamine transporter
Dopamine knock-out mice
The pleasure and the pain
Drugs for Tourette's syndrome
Tourette's and the basal ganglia


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