Efficacy and safety of tianeptine in the treatment of depressive disorders in comparison with fluoxetine
Loo H, Saiz-Ruiz J, Costa e Silva JACE, Ansseau M,
Herrington R, Vaz-Serra A, Dilling H, de Risio S
Service Hospitalo Universitaire de Sante Mentale et de Therapeutique,
Sainte-Anne Hospital, Paris, France.
J Affect Disord 1999 Dec; 56(2-3):109-18


BACKGROUND: Depression is treated by a great variety of antidepressant treatments. SSRIs (such as fluoxetine) are well known: it is, however, sure that further progress is needed and the search for antidepressants with other mechanisms of action (such as tianeptine) or different efficacy is still of interest. METHODS: A multinational study compared tianeptine with fluoxetine in 387 patients with Depressive Episode, or Recurrent Depressive Disorder, or Bipolar Affective Disorder (ICD-10), in a double-blind parallel group design. They were treated for six weeks. RESULTS: At inclusion, no significant difference between groups was shown. Final MADRS scores were 15.7 and 15.8 with tianeptine and fluoxetine, respectively (ITT population) (p = 0.944). MADRS responders were 58% and 56% with tianeptine and fluoxetine, respectively (p = 0.710). No statistical difference was observed for the other efficacy parameters. Thirty-six withdrawals occurred in each group, without any difference for the reasons of discontinuation. There was no major difference between groups for the other safety parameters. CONCLUSIONS: In this study, both tianeptine and fluoxetine exhibited a good efficacy and safety.
Tianeptine: review
Tianeptine and stress
Tianeptine compared
Tianeptine: side-effects
Tianeptine for autistic kids
Tianeptine versus paroxetine
Tianeptine as an antidepressant
Tianeptine, fluoxetine and the rat
Tianeptine and alcohol dependence
Tianeptine for asthmatic depressives
Tianeptine, amineptine and dopamine
Tianeptine and the dopamine D2/D3 receptors
Tianeptine (Stablon, Coaxil): how does it work?

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