Tianeptine raises dopamine and blocks stress-induced
noradrenaline release in the rat frontal cortex

Sacchetti G, Bonini I, Waeterloos GC, Samanin R.
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Eur J Pharmacol. 1993 May 19;236(2):171-5.


The effects of various doses of tianeptine on extracellular concentrations of dopamine were studied in the frontal cortex and nucleus accumbens of the rat. At 5 and 10 mg/kg intraperitoneally, tianeptine raised extracellular dopamine in the nucleus accumbens but only the higher dose caused a significant increase in the frontal cortex. At 10 mg/kg tianeptine significantly raised the concentrations of dihydroxyphenylacetic acid and homovanillic acid in both brain regions. In another experiment, 10 and 20 mg/kg tianeptine did not modify the extracellular concentrations of noradrenaline in the frontal cortex but dose dependently blocked the increase in extracellular noradrenaline caused by restraint stress.
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