Although chemically related to amineptine, the antidepressant tianeptine is not a dopamine uptake inhibitor
by
Vaugeois JM, Corera AT, Deslandes A, Costentin J
Unite de Neuropsychopharmacologie Experimentale,
UPRES-A 6036 CNRS, IFRMP,
UFR de Medecine et Pharmacie de Rouen,
Saint Etienne du Rouvray, France.
Pharmacol Biochem Behav 1999 Jun; 63(2):285-90

ABSTRACT

We investigated whether the antidepressant tianeptine shares the dopamine uptake inhibitory properties of the chemically related antidepressant amineptine. Tianeptine dose dependently (5, 10, 20, 40 mg/kg IP) increased locomotor activity in mice. This stimulant effect (20 mg/kg IP) was dose dependently prevented not only by the D1 dopamine receptor antagonist SCH 23390 (7.5. 15, 30 microg/kg SC), but also by the D2 dopamine receptor antagonist haloperidol (50, 100, 200 microg/kg IP), in contrast to that elicited by dopamine uptake inhibitors. Where the latter prevent dexamphetamine-induced (3 mg/kg SC) reversion of akinesia in mice pretreated with reserpine (4 mg/kg SC, 5 h before test), tianeptine (20 mg/kg IP, 30 min before test) did not. Tested up to a concentration of 10-4 M, tianeptine did neither inhibit the [3H]dopamine uptake into mouse striatal synaptosomes nor compete in vitro with the specific binding of [3H]WIN 35,428 at dopamine transporters from striatal membranes. Finally, in mice injected IV with a tracer dose of [3H]WIN 35,428 (1 microCi), the highest tested dose of tianeptine (40 mg/kg IP) did not reduce the specific binding of the radioligand to striatal dopamine transporters. It is concluded that the antidepressant effect of tianeptine does not depend upon a blockade of the neuronal dopamine transporter.

Serotonin
Amineptine
Tianeptine excess
Tianeptine: overview
Tianeptine and stress
Tianeptine compared
The tinaptine mystery
Tianeptine and dopamine
Tianeptine for autistic kids
Tianeptine versus fluoxetine
The anomalous antidepressant
Tianeptine as an antidepressant
Tianeptine, fluoxetine and the rat
Tianeptine and alcohol dependence
Tianeptine for asthmatic depressives
Tianeptine, amineptine and dopamine
Serotonin reuptake inhibitors v enhancers
Tianeptine and the dopamine D2/D3 receptors
Tianeptine (Stablon, Coaxil): how does it work?

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