Exploratory hypoactivity induced by m-trifluoromethylphenylpiperazine (TFMPP) and m-chlorophenylpiperazine (m-CPP)
by
Klodzinska A, Jaros T, Chojnacka-Wojcik E, Maj J
Institute of Pharmacology,
Polish Academy of Sciences, Krakow.
J Neural Transm Park Dis Dement Sect 1989; 1(3):207-18


ABSTRACT

The action of m-trifluoromethylphenylpiperazine (TFMPP) and m-chlorophenylpiperazine (m-CPP), inhibiting the exploratory activity (ambulation and peeping) of the rat was studied in the open field test. The effects of both these drugs were antagonized by mesulergine, metergoline and mianserin, and partly by methysergide. Spiperone showed an antagonistic action in one (mean) dose only. The effects of TFMPP and m-CPP were not antagonized by ipsapirone, gepirone, cyanopindolol, compound 21009, cyproheptadine, ritanserine, ICS 205930, idazoxan or atropine. The lesion produced by p-chloramphetamine attenuated the effects of TFMPP and abolished those of m-CPP. The obtained results permit an assumption that the TFMPP- and m-CPP-induced decrease in the exploratory activity is mediated probably by 5-HT1C receptors.
DMT
5-HT
MDMA
5-HT2c
Lisuride
Serotonin
Mescaline
LSD and DOB
Psychedelics
Cannabinoids
TFMPP and BZP
TFMPP: structure
LSD and dopamine
Drug discrimination
MAOIs and hallucinogens
Nexus, cathinone, BDB, and MDA


Refs
and further reading

HOME
HedWeb
Nootropics
erythroxylum-coca.com
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family