Psychoendocrine sequelae of
chronic testosterone deficiency

by
Ehrenreich H, Halaris A, Ruether E,
Hufner M, Funke M, Kunert HJ
Department of Psychiatry,
Georg-August-University
and
Max-Planck-Institute for Experimental Medicine,
Gottingen, Germany.
J Psychiatr Res 1999 Sep-Oct; 33(5):379-87


ABSTRACT

The precise role of testosterone in regulating mood, especially in alleviating depression, remains unclear although converging evidence indicates that androgens may exert antidepressant action. A model that may potentially assist in the clarification of androgen-mediated effects on mood is the study of cryptorchid men who may grow up with varying degrees of testosterone deficiency depending on the time in their life when cryptorchism is corrected. In this report, we describe a rare case of bilateral cryptorchism that did not come to the attention of the physician to implement effective substitution with testosterone until much later in adult life. The patient developed severe and suicidal depression which responded solely to testosterone. In addition, the patient experienced a delayed but accelerated puberty without any adverse events. These observations, although based on a single case, provide strong evidence that testosterone may exert powerful antidepressant action in the absence of concomitant antidepressant agents.


Viagra
Yohimbine
Amineptine
Testosterone
Phentolamine
SSRIs and sex
Oxymetholone
The Andropause
Growth hormone
Anabolic steroids
Anorexia and aging
Testosterone and sex
Testosterone withdrawal
Are androgens enjoyable?
Testosterone and cognition
Testosterone and dopamine
Testosterone and the aging male
Testosterone. winning and losing
Testosterone transdermal gel as an antidepressant


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