Thyroid hormone levels and recurrence
of major depression

by
Joffe RT, Marriott M.
Mood Disorders Program and Department of Psychiatry,
Faculty of Health Sciences,
McMaster University, Hamilton, Ontario, Canada.
joffe@fhs.csu.mcmaster.ca
Am J Psychiatry 2000 Oct; 157(10):1689-91


ABSTRACT

OBJECTIVE: The relationship between basal thyroid hormone levels and acute antidepressant response has been studied, but any relationship between basal thyroid hormone levels and long-term course of depressive illness has not been evaluated. METHOD: The authors used a Cox regression survival analysis to evaluate the relationship between life course of depressive illness and basal levels of thyroid hormones (triiodothyronine [T(3)], thyroxine [T(4)], and thyrotropin) in 75 outpatients with unipolar major depressive disorder. RESULTS: Time to recurrence of major depression was inversely related to T(3) levels but not to T(4) levels. CONCLUSIONS: These data may be of clinical interest in view of the fact that T(3) is used to augment antidepressant response.
T3
T3 v T4
Selenium
Dysthymia
Anhedonia
Melancholy
Bipolar disorder
Thyroid hormones
Augmentation strategies
Triiodothyronine (T3): structure
Hypothyroidism and depression
High-dosage thyroxine as an antidepressant
Thyroid hormone, mood modulation and the brain
Mechanisms of thyroid augmentation of antidepressants


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