Suicidality with selective serotonin
reuptake inhibitors: Valid claim?

by
Lapierre YD.
Journal of Psychiatry & Neuroscience.
lapierreyd@aol.com
J Psychiatry Neurosci. 2003 Sep;28(5):340-7


ABSTRACT

The red flags raised by the 1990 clinical reports of increased suicidality associated with treatment with the selective serotonin reuptake inhibitor (SSRI) fluoxetine were followed by anecdotal reports of similar symptoms with other antidepressants of the same class. Recent discussions by Healy have argued in favour of a suicidogenic potential of the SSRIs. This paper reviews the relevant literature addressing the epidemiological data of Western populations and the data accumulated from clinical trial databases in several countries. The evidence currently available does not support the hypothesis that antidepressants or, more specifically, SSRIs cause increased suicidality in patients with depression, nor do they appear to do so in patients treated with these drugs for other reasons.
Suicidality
SSRI suicides?
Suicide: biochemical pathways
How stress triggers depression
Serotonin, the HPA axis and suicide
Suicide rates in the antidepressant era


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