Substance P: a new era, a new role
by
DeVane CL.
Department of Psychiatry and Behavioral Sciences,
Medical University of South Carolina,
Charleston, USA.
devaneL@musc.edu
Pharmacotherapy 2001 Sep;21(9):1061-9


ABSTRACT

Substance P has been extensively studied and is considered the prototypic neuropeptide of the more than 50 known neuroactive molecules. The understanding of substance P has evolved beyond the original concept as the pain transmitter of the dorsal horn. Animal and genetic research, recent developments of nonpeptide substance P antagonists, and important changes in the understanding of neurotransmission have each contributed to the current understanding of substance P After 7 decades, the physiologic role of substance P is known as a modulator of nociception, involved in signaling the intensity of noxious or aversive stimuli. Genetic studies in mice and development of substance P antagonists provide more recent results that support the redefinition of the central role of substance P Evidence suggests that this neuropeptide is an integral part of central nervous system pathways involved in psychologic stress.
Antisense
21st Century
Buprenorphine
Neuropeptide-Y
NMDA antagonists
New antidepressants
Enkephalinase inhibitors
Substance P antagonists
Neurokinins/substance P
New substance P antagonists
Nitric oxide synthase inhibitors
Substance P and major depression
Substance P antagonists as antidepressants
Substance P : effects on sleep, mood, and neuroendocrine function



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