Substance P: a new era, a new role
DeVane CL.
Department of Psychiatry and Behavioral Sciences,
Medical University of South Carolina,
Charleston, USA.
Pharmacotherapy 2001 Sep;21(9):1061-9


Substance P has been extensively studied and is considered the prototypic neuropeptide of the more than 50 known neuroactive molecules. The understanding of substance P has evolved beyond the original concept as the pain transmitter of the dorsal horn. Animal and genetic research, recent developments of nonpeptide substance P antagonists, and important changes in the understanding of neurotransmission have each contributed to the current understanding of substance P After 7 decades, the physiologic role of substance P is known as a modulator of nociception, involved in signaling the intensity of noxious or aversive stimuli. Genetic studies in mice and development of substance P antagonists provide more recent results that support the redefinition of the central role of substance P Evidence suggests that this neuropeptide is an integral part of central nervous system pathways involved in psychologic stress.
21st Century
NMDA antagonists
New antidepressants
Enkephalinase inhibitors
Substance P antagonists
Neurokinins/substance P
New substance P antagonists
Nitric oxide synthase inhibitors
Substance P and major depression
Substance P antagonists as antidepressants
Substance P : effects on sleep, mood, and neuroendocrine function

and further reading

Future Opioids
BLTC Research
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family