Activity of primate subgenual cingulate
cortex neurons is related to sleep

by
Rolls ET, Inoue K, Browning A.
University of Oxford,
Department of Experimental Psychology,
Oxford OX1 3UD, United Kingdom.
Edmund.Rolls@psy.ox.ac.uk
J Neurophysiol. 2003 Jul;90(1):134-42

ABSTRACT

The most frequent type of neuronal response found in the subgenual cingulate cortex (area 25) of the rhesus macaque was a highly significant increase of firing rate when the monkey fell asleep (median rate = 1.6 spikes/s) compared with the awake state (median rate = 0.1 spikes/s). On average, the firing rate of the neurons when awake was 23% of that when the monkeys were asleep. Neurons were not found in this region with responses related to taste, olfactory, and visual stimuli including faces or related to movement. These results are relevant to understanding the function of this region in humans, in which it has been suggested that activation may be related to disengagement from tasks and to induced sadness, both of which we note lead to a more passive or resting behavior. A decrease in the activation of this area in humans has been observed during the recovery from depression, which we note leads to a more active state of behavior.
Options
Dysthymia
Depression
21st century
Bipolar disorder
Hedonic set-point
Hippocampal remodelling
The amygdala and dysthymia
The subgenual anterior cingulate cortex in mood disorders
Depression, an overactive subgenual cingulate region and DBS


Refs
and further reading

HOME
HedWeb
Nootropics
erythroxylum-coca.com
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family