Stress, depression, and anhedonia:
Caveats concerning animal models

by
Anisman H, Matheson K.
Institute of Neuroscience,
Carleton University,
LSRB, Ottawa, Ont., Canada K1S 5B6.
Neurosci Biobehav Rev. 2005 Jul-Sep;29(4-5):525-46


ABSTRACT

Numerous animal models of depression have been advanced, each having multiple attributes and some limitations. This review provides caveats concerning etiologically valid animal models of depression, focusing on characteristics of the depressive subtype being examined (e.g. typical vs atypical major depression, dysthymia, melancholia), and factors that contribute to the interindividual behavioral variability frequently evident in stressor-related behavioral paradigms. These include the stressor type (processive vs systemic stressors), and characteristics of the stressor (controllability, predictability, ambiguity, chronicity, intermittence), as well as organismic variables (genetic, age, sex), experiential variables (stressor history, early life events) and psychosocial and personality factors that moderate stressor reactivity. Finally, a model of depression is reviewed that evaluates the effects of stressors on hedonic processes, reflected by responding for rewarding brain stimulation. Anhedonia is a fundamental feature of depression, and assessment of stressor-related reductions in the rewarding value of brain stimulation, especially when coupled with other potential symptoms of depression, provides considerable face, construct and predictive validity. Stressful events markedly impact rewarding brain stimulation, and this effect varies across strains of mice differentially reactive to stressors, is modifiable by antidepressant treatments, and allows for analyses of the contribution of different brain regions to anhedonic processes. The paradigm is sensitive to several factors known to acts as moderators of stress responses, but analyses remain to be conducted with regard to several such variables.
CRF
LHPA
Stress
Cytokines
Antalarmin
Ketoconazole
Noradrenaline
Corticosteroids
Making animals cry
New antidepressants
Glucocorticoids and mood
Hippocampal remodelling
Neuroendocrinology of stress
HPA axis, serotonin and suicide
Depression, opioids and the HPA
Antidepressants and new brain cells
Are antidepressants neuroprotective?
The corticosteroid hypothesis of depression


Refs
and further reading

HOME
HedWeb
Nootropics
Cocaine.org
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family