Sub-chronic treatment with an extract of Hypericum perforatum (St John's wort) significantly reduces cortisol and corticosterone in the rat brain
Franklin M, Reed A, Murck H.
Department of Psychiatry, University of Oxford,
Warneford Hospital, OX3 7JX, Oxford, UK
Eur Neuropsychopharmacol. 2004 Jan;14(1):7-10


Extracts of Hypericum perforatum (HP) have been shown to be effective for the treatment of mild to moderate depression. Its mode of action has not been fully elucidated. An increase in plasma and cerebrospinal fluid (CSF) cortisol is frequently observed in depression. Studies have suggested that HP might alter brain cortisol and corticosterone through its effect on multidrug transporter glycoprotein (Pgp). We investigated the effect of sub-chronic treatment with an extract of HP (LI 160) on brain levels of corticosterone and cortisol in the rat. Results show that HP significantly reduced corticosterone and cortisol in brain frontal cortex tissue. These changes are not reflected in serum. These findings may be important with respect to HPs mode of antidepressant action.

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Natural drugs
Depression: treatment
St John's wort and depressed animals
St John's wort: a smart antidepressant?
Hypericum/St John's wort (Kira, Alterra)
St John's wort for mild / moderate depression
St John's wort as an antidepressant : mechanisms
St. John's Wort for minor depressive symptoms or dysthymia
Natural antidepressants: Hypericum perforatum/St John's wort

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