Selective serotonin-reuptake inhibitors: an update
by
Masand PS, Gupta S
Psychiatric Consultation Service,
Regional Psychopharmacology Consultation and Training Program,
SUNY Health Science Center at Syracuse, NY 13210, USA.
Harv Rev Psychiatry 1999 Jul-Aug; 7(2):69-84


ABSTRACT

Selective serotonin-reuptake inhibitors (SSRIs), including fluoxetine, sertraline, paroxetine, fluvoxamine, and citalopram, represent an important advance in the pharmacotherapy of mood and other disorders. They are chemically unrelated to tricyclic, heterocyclic, and other first-generation antidepressants. SSRIs are the treatment of choice for many indications, including major depression, dysthymia, panic disorder, obsessive-compulsive disorder, eating disorders, and premenstrual dysphoric disorder, because of their efficacy, good side-effect profile, tolerability, and safety in overdose, as well as patient compliance. A review of the literature was conducted using Medline and the terms "SSRIs," "fluoxetine," "sertraline," "paroxetine," "fluvoxamine," and "citalopram." Articles were limited to those published in English within the last 15 years. The search revealed that indications for antidepressants include unipolar depression, dysthymia, bipolar depression, treatment-resistant depression, depression in the medically ill, panic disorder, obsessive-compulsive disorder, eating disorders, social phobia, and premenstrual dysphoric disorder. One SSRI, fluoxetine, has demonstrated safety in pregnancy. Side effects of SSRIs include gastrointestinal disturbances, headache, sedation, insomnia, activation, weight gain, impaired memory, excessive perspiration, paresthesia, and sexual dysfunction. predictable through an understanding of the different serotonergic pathways.


SSRIs
Options
Anxiety
Serotonin
Sertraline
Fluoxetine
Citalopram
Paroxetine
New SSRIs
Fluvoxamine
SSRIs: review
SSRIs in sewage
SSRI mechanisms
SSRIs and emotion
Serotonin research
Neuropharmacology of serotonin
Serotonin and the genetics of depression
Males, females, serotonin and depression
Depression: recent developments and controversies
Are SSRI antidepressants little better than placebos?
Selective serotonin reuptake inhibitors reduce emotional lability

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