Amotivational syndrome associated with selective
serotonin reuptake inhibitors in children and adolescents

by
Garland EJ, Baerg EA.
University of British Columbia,
Mood and Anxiety Disorders Clinic,
British Columbia's Children's Hospital,
Vancouver Community Mental Health Service, Canada.
jgarland@cw.bc.ca
J Child Adolesc Psychopharmacol 2001 Summer;11(2):181-6


ABSTRACT

A frontal lobe syndrome has previously been reported in adults treated with selective serotonin reuptake inhibitors (SSRIs), but not in children. Five typical cases of apathy and lack of motivation, one accompanied by disinhibition, are described in a child and four adolescents. Symptoms were dose related and reversible. The subtlety of symptoms, lack of insight in patients, disabling effects, and delayed onset indicate a need for clinicians to inform families of these potential symptoms when SSRIs are prescribed.
SSRIs
Apathy
Dopamine
Dysthymia
Melancholy
Amisulpride
Methylphenidate
Pharmacogenetics
Stress and anhedonia


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