Does the melanin-concentrating hormone
antagonist SNAP-7941 deserve 3As?

by
Doggrell SA.
School of Biomedical Sciences,
The University of Queensland,
QLD 4072, Australia.
s_doggrell@yahoo.com
Expert Opin Investig Drugs. 2003 Jun; 12(6): 1035-8.


ABSTRACT

Melanin-concentrating hormone (MCH) is orexigenic (stimulates food intake). Two receptors for MCH have been identified in humans, MCH1-R and MCH2-R. SNAP-7941 is a small molecule MCH1-R antagonist. SNAP-7941 inhibits MCH-induced food intake in rats. SNAP-7941 alone reduced weight gain in young growing rats and in mature rats fed a high-fat diet. Preliminary testing with SNAP7941 in animal models of depression and anxiety shows it has antidepressant and anxiolytic effects. SNAP7941 should undergo further development as an anorectic, antidepressant and anxiolytic.
TCAs
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Atypical depression
Retarded depression
Antidepressants and cell growth
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Antidepressants: tolerability and adherence
The immune system, depression and antidepressants
SNAP-7941 : anorectic, antidepressant and anxiolytic effects


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