Non-nicotinic neuropharmacological strategies
for nicotine dependence: beyond bupropion

by
Cryan JF, Gasparini F, van Heeke G, Markou A.
Neuroscience Disease Area,
The Novartis Institutes for BioMedical Research,
WSJ 386.344Novartis Pharma AG. CH-4002,
Basel, Switzerland.
jihn_f._cryan@pharma.novatis.com
Drug Discov Today. 2003 Nov 15;8(22):1025-34


ABSTRACT

Smoking is a major health problem and is propelled, at least in part, by the addictive properties of nicotine. Two types of pharmacological therapies have been approved for smoking cessation by the US Food and Drug Administration. The first therapy consists of nicotine replacement, substituting the nicotine from cigarettes with safer nicotine formulations. The second therapy is bupropion (Zyban), an atypical antidepressant, whose use has raised much debate as to how a non-nicotine-based agent can aid in smoking cessation. This review focuses on recent advances that could lead to the development of improved novel pharmacological treatments. These strategies focus on altering reward processes in the brain by modulating various neurotransmitter systems: the most promising include dopamine D(3) receptor antagonists, noradrenaline reuptake inhibitors, GABA(B) receptor agonists, metabotropic glutamate 5 (mGluR5) receptor antagonists, cannabinoid CB1 receptor antagonists, and corticotropin releasing factor (CRF) 1 receptor antagonists.
MAO
Insula
Nicotine
Tobacco
Cotinine
Bupropion
Cigarettes
Bromocriptine
Smoking and MAO
Bupropion SR [Zyban]
Nicotine versus crack
The hedonic set-point
Cigars, bidis, and kreteks
Antidepressants: nicotine
The neural basis of addiction
Bupropion for nicotine quitters
Bupropion and nicotinic receptors
Bupropion (Zyban) for cigarette smokers
Quitting smoking: the role of antidepressants
Nicotine self-administration and increased reward-sensitivity


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