Rate of switch from depression into mania after
therapeutic sleep deprivation in bipolar depression

by
Colombo C, Benedetti F, Barbini B, Campori E, Smeraldi E
IRCCS Istituto Scientifico Ospedale San Raffaele,
Department of Neuropsychiatric Sciences,
University of Milan,
School of Medicine, Italy.
Psychiatry Res 1999 Jun 30; 86(3):267-70


ABSTRACT

Sleep deprivation is a potentially useful non-pharmacological treatment for depression. A relationship between sleep loss and the onset of mania has been reported, so it is possible that a switch from depression into mania after sleep deprivation might be expected in bipolar depressed patients who are treated with sleep deprivation. In a sample of 206 bipolar depressed treated with three cycles of sleep deprivation, alone or in combination with heterogeneous medications, we observed a 4.85% switch rate into mania and a 5.83% switch rate into hypomania. These percentages are comparable to those observed with antidepressant drug treatments.
Cocaine
Caffeine
Dopamine
Adenosine
Sleepiness
Noradrenaline
Atypical depression
Retarded depression
Total sleep deprivation
Drugs for sleep and insomnia
Hypersomnia and depression
Sleep deprivation and dopamine
Sleep deprivation and depression


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