Controlled release levodopa in Parkinson's disease: influence of selection criteria and conversion recommendations in the clinical outcome of 450 patients. STAR Study Group
by
Linazasoro G, Grandas F, Martinez Martin P, Bravo JL.
Center for Neurology and Functional Neurosurgery,
Clinica Quiron, San Sebastian, Spain.
Clin Neuropharmacol 1999 Mar-Apr;22(2):74-9


ABSTRACT

We present the results of an open, prospective, multicentric study including 450 patients with mild to moderate Parkinson's disease (PD) converted from standard Sinemet to Sinemet CR (controlled release; Dupont Pharma, Pavia, Italy). Patients with complex fluctuations and diphasic dyskinesias were excluded and the conversion was made after some recommendations, depending on the clinical problems and the daily dosage and administration schedule of standard (STD) Sinemet. The condition of more than 60% of the patients improved after the change and 80% of them preferred the CR formulation by the end of the study. We found a moderate, but significant, improvement in most of the efficacy parameters used, such as the Unified Parkinson's Disease Rating Scale (UPDRS), the Schawb and England scale, and dyskinesias and sleep questionnaires. Forty-five patients (10%) discontinued the study due to adverse effects (mainly gastrointestinal disturbances, functional deterioration, and dyskinesias). We conclude that Sinemet CR is a useful and safe therapeutic option in patients with mild and moderate PD. Selection of the patients is the most important outcome factor.
Sinemet
Selegiline
Levodopa
Cabergoline
Bromocriptine
Dopaminergics
Pramipexole : review
Caffeine and Parkinson's disease
Tramadol and Parkinson's disease
Mianserin and Parkinson's disease
Selegiline and Parkinson's disease
Apomorphine and Parkinson's disease
Hedonistic homeostatic dysregulation
Parkinsonian signs/symptoms in depressives
L-dopa in the treatment of Parkinson's disease


Refs
and further reading

HOME
HedWeb
Nootropics
erythroxylum-coca.com
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family