Sildenafil for iatrogenic serotonergic antidepressant medication-induced sexual dysfunction in 4 patients
Nurnberg HG, Lauriello J, Hensley PL, Parker LM, Keith SJ
Department of Psychiatry,
School of Medicine,
University of New Mexico Health Sciences Center,
Albuquerque 87131-5456, USA.
J Clin Psychiatry 1999 Jan; 60(1):33-5
ABSTRACTOBJECTIVE: To evaluate the effect of sildenafil on iatrogenic serotonergic antidepressant-induced sexual dysfunction. METHOD: Four outpatients (2 men, 2 women) who developed sexual dysfunction (erectile impotence, anorgasmia) during treatment with a serotonin reuptake inhibitor antidepressant for psychiatric disorder were selected. Each subject was initially prescribed sildenafil 50 mg to be taken approximately 1 hour before sexual activity. The dose was increased to 100 mg for a partial or failed response. RESULTS: Four cases are detailed in case report fashion. All 4 had rapid reversal of their sexual dysfunction, usually with the first dose. Reversal equates to 1 successful use of sildenafil in each of 2 patients and 3 uses in 2 patients. CONCLUSION: Sildenafil may be an effective treatment for serotonergic antidepressant-induced sexual dysfunction and deserves further evaluation in randomized placebo-controlled studies.
The Viagra Revolution
Viagra: clinical efficacy
Viagra: clinical experience
Semen as an antidepressant?
The pharmacology of penile erection
Drugs to promote female sexual desire
Is sildenafil (Viagra) an antidepressant?
Viagra v Levitra as recreational sex-drugs
Sidenafil (Viagra) enhances oxytocin release
Sildenafil (Viagra): prescribing information (PDF)
Sildenafil (Viagra) v vardenafil (Nuviva) v tadalafil (Cialis)
Sildenafil (Viagra) for antidepressant-induced sexual dysfunction
and further reading
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World
The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family