Effects of secobarbital on human aggressive
and non-aggressive responding

by
Cherek DR, Spiga R, Steinberg JL.
Department of Psychiatry and Behavioral Sciences,
University of Texas Medical School,
Houston. Drug Alcohol Depend 1989 Aug; 24(1):21-9


ABSTRACT

This study examined the effects of secobarbital on human aggressive responding in a controlled laboratory setting. Sixty minutes prior to experimental sessions, male subjects were administered either placebo or 50, 100 or 200 mg per 70 kg of body weight doses of secobarbital double-blind. During these sessions, subjects could press a button to accumulate points exchangeable for money (non-aggressive response) or press another button ostensibly to subtract points from a fictitious person (aggressive response). Aggressive responding was occasioned by subtracting points from the subject. Subjects were instructed that points were subtracted by another person. Aggressive responding was maintained by contingent presentation of periods free of point subtractions, i.e., provocations. Acute secobarbital administration produced dose-dependent decreases in non-aggressive responding, and increases in aggressive responding.
GABA
Anxiety
Valerian
Gepirone
Buspirone
Zopliclone
Fengabine
Adinazolam
Barbiturates
Methaqualone
Benzodiazepines
Chronic insomnia
Secobarbital (Seconal) : structure


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