RNA-mediated gene regulation system:
Now and the future (Review)
Yin JQ, Wan Y.
Division of Health Science and Technology,
Thorn Building, Boston, MA 02115, USA.
Int J Mol Med 2002 Oct;10(4):355-65
ABSTRACTThe discovery of RNA-mediated gene regulation system has brought human beings another big surprise on the wisdom and power of nature. Nature can not only create genetic codes with 4 nucleotides and produce proteins with 21 amino acids, but also control their intermediates, mRNAs, with double-stranded RNA molecules composed of approximately 22 nt. It has been clear that approximately 22 nt dsRNAs can specifically and efficiently modulate gene expression through sequence-specific targeting thus silencing of RNA. This system promises to be an excellent model for the identification of gene functions and the exploitation of gene expression and phenotype alteration, and a promising way for the prevention and treatment of human diseases.CRF
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