Some behavioural effects of risperidone
in rats: comparison with haloperidol

by
Nowakowska E, Chodera A,
Kus K, Rybakowski J.
Department of Pharmacology,
Karol Marcinkowski University of Medical Sciences
in Poznan, Poland.
Eur Neuropsychopharmacol 1999 Sep;9(5):421-6


ABSTRACT

Risperidone is a dopaminergic as well as a 5-HT2 antagonist. The drug was found to exert beneficial effects on both positive and negative symptoms of schizophrenia. Since recently, schizophrenia is regarded as a composite of not only positive and negative but also affective and cognitive symptoms, in this study the effects of risperidone compared with typical neuroleptic haloperidol, on affective and cognitive functions were investigated in rats (anxiolytic, antidepressive and memory tests). We found, that in contrast to haloperidol, risperidone had antidepressive, anxiolytic and memory enhancing effects. The results obtained correspond with favourable effects of risperidone on mood disturbances and cognitive functions of schizophrenic patients observed under clinical conditions.
Clozapine
Glutamate
Quetiapine
Risperidone
Antipsychotics
NMDA antagonists
New antipsychotics
Psychotic depression
Atypical antipsychotics
Bipolars v schizophrenics
Drug-induced weight gain
Schizophrenia: neuroleptics
Serotonin model of schizophrenia
Dopamine model of schizophrenia
Atypicals versus traditional antipsychotics
Risperidone (Risperdal): prescribing information (PDF)


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