Effects of risperidone on affective symptoms
in patients with schizophrenia

Peuskens J, Van Baelen B, De Smedt C, Lemmens P
Department of Psychiatry,
University Centre St Jozef,
Kortenberg, Belgium.
Int Clin Psychopharmacol 2000 Nov; 15(6):343-9


The effects of risperidone on affective symptoms were determined by an analysis of pooled data from six double-blind trials of risperidone versus haloperidol in 1254 patients with chronic schizophrenia. Symptoms indicating mania were assessed by the Positive and Negative Syndrome Scale (PANSS) excitement and grandiosity items and by the excited cluster (excitement, hostility, uncooperativeness, and poor impulse control); anxious / depressive symptoms were assessed by the PANSS anxious / depressive cluster (somatic concern, anxiety, guilt feelings, and depression). Mean change scores from baseline to endpoint were compared in patients receiving risperidone, haloperidol or placebo by analysis of variance with factors for trial and baseline score included in the model. In all patients, change scores on excitement and grandiosity items and excited and anxious / depressive clusters were significantly greater for risperidone than for haloperidol or placebo. Dropouts due to inefficacy were less frequent with risperidone (5 of 59; 8%) than with haloperidol (7 of 38; 18%) or placebo (8 of 10; 80%). In patients with anxious / depressive symptoms at baseline (anxiety / depression cluster score > or = the median), anxiety / depression scores decreased significantly more with risperidone than with haloperidol, and symptom reduction occurred faster with risperidone. These results are consistent with previous reports and suggest that risperidone is more efficacious than haloperidol for affective symptoms in patients with schizophrenia.
NMDA antagonists
New antipsychotics
Psychotic depression
Paliperidone (Invega)
Atypical antipsychotics
Risperidone v haloperidol
Bipolars v schizophrenics
Schizophrenia: neuroleptics
Serotonin model of schizophrenia
Dopamine model of schizophrenia
Big Pharma and drugs for schizophrenics
Atypical antipsychotics for schizophrenia
Atypicals versus traditional antipsychotics
Risperidone (Risperdal): prescribing information (PDF)

and further reading

Future Opioids
BLTC Research
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family