Does quetiapine have mood altering properties?
by
Mishra A, Moore PB, Hobbs R.
Mental Health Unit, Leazes Wing,
Royal Victoria Infirmary,
Newcastle Upon Tyne., Email: achdoc@aol.com
J Psychopharmacol. 2004 Jun;18(2):281-4.


ABSTRACT

We present a series of three cases who developed manic symptoms on introduction of quetiapine to their medication regime. All were male, with long-standing psychotic illnesses (schizophrenia/schizoaffective disorder), relatively well maintained on medication until their deterioration which prompted a review of their medication. The dose range of prescribed quetiapine was 300-800 mg daily. Two patients had previously received antidepressants without displaying manic symptoms. The mania subsided on withdrawal of quetiapine in two patients. The third patient continued on quetiapine but with the addition of zuclopenthixol depot. Sodium valproate was prescribed to the other two patients, and quetiapine was discontinued. These cases indicate that a side-effect of quetiapine may be mood elevation. An ability to elevate mood while controlling psychoses would be helpful in the treatment of post-psychotic and bipolar depression. Its clinical importance in the control of manic episodes, for which atypical antipsychotics are used increasingly, is uncertain.
Mania
5-HT1a
Quetiapine
Amisulpride
Gabapentin
Lamotrigine
Bipolar disorders
Quetiapine: efficacy
The manic spectrum
Paliperidone (Invega)
Antipsychotics: review
Bipolar treatment guidelines
Gabapentin, pain and depression
Atypical neuroleptics and cognition
Quetiapine (Seroquel) for bipolar disorder
Quetiapine (Seroquel): prescribing information (PDF)


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