Psilocybin as a discriminative stimulus:
lack of specificity in an animal behavior model for 'hallucinogens'

by
Koerner J, Appel JB
Psychopharmacology (Berl) 1982; 76(2):130-5


ABSTRACT

Fifteen rats were trained to discriminate between the tryptamine hallucinogen psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine; 1.0 mg/kg) and saline in a two-lever choice task. Dose-response and time-response curves were obtained. The psilocybin cue generalized to psilocin (the dephosphorylated congener of psilocybin) and to the prototypical indoleamine hallucinogen LSD, but not to the phenylethylamine hallucinogen mescaline. These results indicate that the hallucinogenic effects of these drugs in humans may not be identical with their discriminative stimulus functions in animals, and that these four compounds may not be members of a single drug class. The term 'hallucinogen' may thus be a misnomer in the context of drug discrimination studies in nonhumans.
DMT
5-HT
MDMA
Dopamine
Serotonin
Psicocybe
Mescaline
LSD and DOB
Psychedelics
Cannabinoids
Psychedelic honey
Psilocybin: structure
Thai magic mushrooms
MAOIs and hallucinogens
Nexus, cathinone, BDB, and MDA
Hofmann's LSD: My Problem Child
Jesus, magic mushrooms and the Last Supper
Psilocybin : psychological and physiological effects


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