A review of pramipexole and its
clinical utility in Parkinson's disease

by
Biglan KM, Holloway RG.
University of Rochester, Department of Neurology,
1351 Mt. Hope Avenue, Suite 220,
Rochester, NY 14620, USA. Kbiglan@mct.rochester.edu
Expert Opin Pharmacother 2002 Feb;3(2):197-210


ABSTRACT

Parkinson's disease (PD) is a common neurodegenerative disorder characterised by selective loss of dopaminergic neurones in the substantia nigra and resulting in progressive disability. Therapy has focused on replacing depleted dopamine (DA) via supplementation with levodopa or DA agonists. Pramipexole (Mirapex((R)), Pharmacia Corp.) has recently been approved for the treatment of PD. Evidence from preclinical studies and clinical trials have proven the effectiveness of this agent in ameliorating the symptoms of PD. There is also non-human evidence that pramipexole may be neuroprotective and could therefore possibly slow disease progression; however, this has yet to be proven in humans. The use of pramipexole may be limited by its side effect profile compared to standard therapies and its relatively higher cost compared to levodopa. Despite these concerns, pramipexole does have a role in the treatment of PD in all stages of the illness and may arguably be the treatment of choice in early disease. In addition to its use in PD, pramipexole has shown some utility in the treatment of restless legs syndrome (RLS), depression and schizophrenia.
Options
Piribedil
Pergolide
Selegiline
Roxindole
Dopamine
Bupropion
Fluoxetine
Citalopram
Amineptine
Somnolence
Parkinson's disease
Restless leg syndrome
Cocaine discrimination
Cabergoline (Dostinex)
Pramipexole and ropinirole
Pramipexole as an antidepressant
Pramipexole, dopamine D2 and D3
Pramipexole plus sertraline (Zoloft)
Pramipexole for treatment-resistant depression
Pramipexole (Mirapex): prescribing information (PDF)
Pramipexole (Mirapex) and ropinirole (Requip) for bipolars


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