Depression in Parkinson's disease:
conceptual issues and clinical challenges

by
Leentjens AF.
Department of Psychiatry,
Maastricht University Hospital,
P.O. Box 5800, 6202 AZ Maastricht,
the Netherlands,
Email: a.leentjens@np.unimaas.nl
J Geriatr Psychiatry Neurol. 2004 Sep;17(3):120-6


ABSTRACT

BACKGROUND: Depression frequently accompanies Parkinson's disease (PD) and may have a negative impact on activities of daily living, cognitive performance, and quality of life. Because of the symptom overlap between the 2 disorders, it may be difficult to recognize depression in PD. Moreover, the partially shared pathophysiology may make it difficult to treat depressive symptoms without influencing motor or cognitive function. OBJECTIVE: To review the current knowledge of the epidemiology, etiology, pathophysiology, and treatment of depression in patients with Parkinson's disease. METHOD: Discussion of recent studies and relevant literature. CONCLUSION: Not only conceptually but also in terms of etiology, pathophysiology, and treatment, the relationship between PD and depression remains a challenge. There are still many questions to be answered. In the therapeutic domain, large, placebo-controlled trials are necessary to evaluate the efficacy of antidepressant treatment and allow the development of evidence-based guidelines.


Selegiline
Rasagiline
Cabergoline
Bromocriptine
Dopaminergics
Parkinsonian pain
Pramipexole : review
Parkinson's disease: resources
Caffeine and Parkinson's disease
Tramadol and Parkinson's disease
Mianserin and Parkinson's disease
Selegiline and Parkinson's disease
Apomorphine and Parkinson's disease
Parkinsonian signs/symptoms in depressives
L-dopa in the treatment of Parkinson's disease


Refs
and further reading

HOME
HedWeb
Nootropics
erythroxylum-coca.com
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family