Noradrenaline-degrading activity of monoamine oxidase is localized in noradrenergic neurons of the locus coeruleus of the rat
by
Hasegawa Y, Hida T, Arai R
Department of Anatomy,
Fujita Health University School of Medicine,
Toyoake, Aichi, Japan. Neurosci Lett 1999 Apr 2; 264(1-3):61-4


ABSTRACT

We found intense monoamine oxidase (MAO) activity in rat locus coeruleus (LC) neurons by means of a histochemical method using noradrenaline as a substrate. This MAO activity was abolished by clorgyline, a specific inhibitor of MAO type A. Fluorescence immunohistochemistry for tyrosine hydroxylase (TH) combined with MAO histochemistry revealed intense MAO activity in virtually all TH-immunoreactive LC neurons (i.e. noradrenergic neurons). The results indicate that noradrenaline produced in LC neurons might be degraded by MAO type A activity.

MAO
RIMAs
MAOIs
Reward
Clorgyline
Phenelzine
Brofaromine
Moclobemide
Isocarboxazid
Tranylcypromine
Tyrosine hydroyxlase
Noradrenaline and mood

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