Antidepressant-like action of nicotine in forced swimming test and brain serotonin in mice
Suemaru K, Yasuda K, Cui R, Li B, Umeda K, Amano M,
Mitsuhashi H, Takeuchi N, Inoue T, Gomita Y, Araki H.
Division of Pharmacy, Ehime University Hospital,
Shitsukawa Toon, Ehime, 791-0295, Japan.
Physiol Behav. 2006 Jul 30;88(4-5):545-9.


An antidepressant-like action of nicotine has been suggested in the forced swimming test. The aim of the present study was to evaluate the relationship between the antidepressant-like action of nicotine and brain serotonin (5-HT) in mice. Nicotine at a dose of 0.2 mg/kg significantly (p < 0.05) decreased the duration of immobility time in forced swimming test. However, nicotine (0.01-1 mg/kg, s.c.) had no effect on locomotor activity in open-field test. Dopamine turnover in mouse whole brain was increased by nicotine (0.01-1 mg/kg, s.c.) in a dose-dependent manner, and nicotine at a dose of 0.05 mg/kg showed a significant increases in 5-HT turnover. Nicotine at a dose of 0.05 mg/kg markedly enhanced head twitch responses induced by (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), a selective 5-HT2A/2C receptor agonist. These findings suggest that the involvement of nicotinic and serotonergic systems in the antidepressant-like effects of nicotine.
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