Fluoxetine versus moclobemide: cross-comparison
between the time courses of improvement

by
Stassen HH, Angst J, Delini-Stula A
Psychiatric University Hospital Zurich,
Research Department,
Switzerland.
k454910@bli.unizh.ch
Pharmacopsychiatry 1999 Mar;32(2):56-60


ABSTRACT

Competitive statistical methods were used in a meta-analysis of the data of 440 fluoxetine-treated and 437 moclobemide-treated patients in order to address the issue of the timing of recovery from depression, and to elucidate potential differences in the onset of action between the two different classes of antidepressants. In spite of large biochemical and pharmacological differences, fluoxetine and moclobemide turned out to be virtually identical with regard to the overall efficacy, proportions and time characteristics of premature withdrawal, and most notably, the time course of recovery. The onset of improvement occurred in the majority of cases within the first two weeks of treatment and was highly predictive for the outcome after six weeks. The analyses yielded no indication of a delayed onset of action of antidepressants. Given the apparent nonspecificity of antidepressants, together with their relatively modest response rates, future research will need consider whether mechanisms different from those related to the monoaminergic systems may be involved in the pathogenesis of depression.
MAO
RIMAs
Phenelzine
Brofaromine
Isocarboxazid
Tranylcypromine
MAOIs and dopamine
Moclobemide : history
Moclobemide v sertraline
Moclobemide and whisky
Moclobemide for migraine
Moclobemide and dysthymia
Moclobemide v tranylcypromine
Moclobemide and panic disorder
Moclobemide and sexual function
Moclobemide and MDMA / Ecstasy
Moclobemide and demented depressives
Moclobemide (Manxerix, Aurorix) : review
Moclobemide and hippocampal neurogenesis


Refs
and further reading

HOME
HedWeb
Nootropics
erythroxylum-coca.com
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family