Subjective effects of antidepressants: a pilot study of the varieties of antidepressant-induced experiences in meditators.
by
Bitner R, Hillman L, Victor B, Walsh R.
Department of Psychiatry,
University of California-Irvine,
College of Medicine, Irvine, California, USA.
J Nerv Ment Dis. 2003 Oct;191(10):660-7


ABSTRACT

The use of antidepressants continues to increase, yet relatively little is known about their precise subjective effects, and there is growing concern about subtle psychological side effects. One novel investigative approach to these problems may be to use introspectively trained subjects such as meditators. Experienced meditators recently taking antidepressants rated antidepressant effects on multiple dimensions of experience and reported significant emotional, motivational, and cognitive effects and benefits. This study suggests that a) meditators may benefit both clinically and meditatively from antidepressants, b) meditators may provide significant novel information on antidepressant effects, c) meditators may prove valuable for phenomenological investigations of psychopathology, drug effects, and therapies, d) meditation may prove a helpful maintenance therapy for depression, and e) enhanced equanimity may contribute to the broad therapeutic efficacy of antidepressants.
Antidepressants
Biogenic amines
Noradrenaline depletion
Catecholamine depletion
An individualised approach
New ways to treat depression
How do antidepressants work?
Monoamines and 'novel' antidepressants
Males, females, serotonin and depression
The monoamine hypothesis of depression
Mood enhancement via stem cell therapy
The catecholamine hypothesis of depression
Treatment-resistant depression; new therapies
Are SSRI antidepressants little better than placebos?
Antidepressant comparisons: remission and response
Depression and antidepressants: remission, dropouts, and ADRs
The placebo vs nocebo effect: opioid and dopaminergic substrates
Does early improvement triggered by antidepressants predict response/remission?
Selective publication of clinical trials leads to unrealistic estimates of antidepressant efficacy


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