The acute effect of the bioprecursor of the selective brain
MAO-A inhibitor, MDL 72392, on rat pineal melatonin biosynthesis

by
Oxenkrug GF, Requintina PJ, Yuwiler A, Palfreyman MG.
Psychiatry Service, VAMC,
Providence, RI 02908.
J Neural Transm Suppl. 1994;41:377-9


ABSTRACT

The bioprecursor amino acid MDL 72394 is decarboxylated by aromatic L-amino acid decarboxylase (AADC) to liberate MDL 72392, an irreversible selective MAO-A inhibitor. Pretreatment with the AADC inhibitor carbidopa, which does not penetrate the brain-blood barrier, prevents the liberation of the MAO-A inhibitor outside the brain and results in exclusive inhibition of brain MAO-A. We found that systemic administration of MDL 72394 (0.5 mg/kg, i.p.) stimulated rat pineal melatonin biosynthesis. Carbidopa, in a dose-dependent manner, attenuated or completely prevented MDL-induced stimulation of melatonin biosynthesis in the pineal gland located outside the blood-brain-barrier.
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