Acute Treatment of Mania: An Update on New Medications
Gajwani P, Kemp DE, Muzina DJ, Xia G, Gao K, Calabrese JR.
Assistant Professor of Psychiatry,
Case School of Medicine,
Clinical Director, Mood Disorders Program,
University Hospitals Case Medical Center,
11400 Euclid Avenue, Suite 200,
Cleveland, OH 44106, USA.
Curr Psychiatry Rep. 2006 Dec;8(6):504-509.


Acute mania is frequently a medical emergency requiring hospitalization for behavioral control, rapid resolution of irritability, agitation, de-escalation of mood, and decreasing of risk-taking behavior. Lithium efficacy in the management of acute mania was reported in 1949 and approved by the US Food and Drug Administration (FDA) in 1970. Chlorpromazine, from the class of typical antipsychotics, was approved for treatment of bipolar disorder in 1973. Typical antipsychotics were frequently used alone and as adjunct for the treatment of bipolar mania for the next 2 decades. Divalproex was approved by the FDA for the treatment of acute mania in 1994. Since the approval of olanzapine in 2000, all five atypical antipsychotics, namely risperidone (2003), quetiapine (2004), ziprasidone (2004), and aripiprazole (2004), have been approved by the FDA for the management of acute mania. Clozapine is the only atypical antipsychotic not FDA approved for any phase of bipolar disorder. This article will systematically review some of the major studies published, randomized controlled monotherapy, and
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Protein kinase C
Bipolar disorders
Drugs for bipolars
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The manic spectrum
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The many faces of mania
Genius and psychopathology
Ouabain-induced rodent mania?
Mania: lithium versus divaplroex
Manic thinking, happiness and depression
Dysthymia, hyperthymia and cyclothymia

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