Spotlight on escitalopram in the management
of major depressive disorder

by
Murdoch D, Keam SJ.
Adis International Limited,
Auckland, New Zealand.
CNS Drugs. 2006;20(2):167-70.


ABSTRACT

Escitalopram (Cipralex((R)), Lexapro(trade mark)), the active S-enantiomer of the racemic SSRI citalopram (RS-citalopram), is a highly selective inhibitor of the serotonin transporter protein. It possesses a rapid onset of antidepressant activity, and is an effective and generally well tolerated treatment for moderate-to-severe major depressive disorder (MDD). Pooled analyses from an extensive clinical trial database suggest that escitalopram is consistently more effective than citalopram in moderate-to-severe MDD. Preliminary studies suggest that escitalopram is as effective as other SSRIs and the extended-release (XR) formulation of the serotonin/noradrenaline (norepinephrine) reuptake inhibitor venlafaxine, and may have cost-effectiveness and cost-utility advantages. However, additional longer-term, comparative studies evaluating specific efficacy, tolerability, health-related quality of life and economic indices would be helpful in definitively positioning escitalopram relative to these other agents in the treatment of MDD. Nevertheless, available clinical and pharmacoeconomic data indicate that escitalopram is an effective first-line option in the management of patients with MDD.
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Escitalopram (Lexapro)
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SSRIs and panic disorder
Citalopram and selegiline
Citalopram v amitriptyline
Citalopram and depression
Citalopram and panic disorder
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Citalopram and eating disorders
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Citalopram and depression: trials
Big Pharma meets Madison Avenue
Citalopram: oral versus intravenous
Serotonin and the genetics of depression
Single isomer SSRI escitalopram as an antidepressant
Escitalopram (Lexapro) : mechanism of antidepressant action


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