Escitalopram: A New SSRI for the Treatment
of Depression in Primary Care

by
Culpepper L.
Department of Family Medicine
Boston University Medical Center, Boston, Mass.
Prim Care Companion J Clin Psychiatry. 2002 Dec;4(6):209-214


ABSTRACT

Escitalopram is the S-enantiomer of the racemic compound citalopram, a selective serotonin reuptake inhibitor (SSRI) widely used for the treatment of depression. This review describes the current body of pharmacologic and clinical evidence supporting the use of escitalopram for the treatment of depression and anxiety. Preclinical studies have confirmed that it is primarily this molecule that provides the inhibition of serotonin reuptake responsible for the antidepressant effect of citalopram, with minimal-to-nonexistent affinity for other receptor sites. Clinical trials of escitalopram in depressed patients indicate that escitalopram, 10 mg/day, is as effective as 40 mg/day of its parent compound, citalopram, with an excellent safety and tolerability profile. Because of its increased selectivity, escitalopram represents a refinement in SSRI therapy for symptoms of depression and anxiety. This article also explores the implications of a more selective SSRI on the management of depressed patients in the primary care clinical practice.
Chiral chimera?
Escitalopram (Lexapro)
Citalopram and ecstasy
SSRIs and panic disorder
Citalopram and selegiline
Citalopram v amitriptyline
Citalopram and depression
Citalopram and panic disorder
Serotonin and romantic lovers
Citalopram and eating disorders
Citalopram maintenance therapy
Citalopram and depression: trials
Big Pharma meets Madison Avenue
Citalopram: oral versus intravenous
Serotonin and the genetics of depression
Single isomer SSRI escitalopram as an antidepressant
Escitalopram (Lexapro) : mechanism of antidepressant action


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