Inositol reduces depressive-like behaviors
in two different animal models of depression

Einat H, Karbovski H, Korik J, Tsalah D, Belmaker RH
Beer Sheva Mental Health Center,
Faculty of Health Sciences,
Ben-Gurion University of the Negev, Israel.
Psychopharmacology (Berl) 1999 May;144(2):158-62


RATIONALE: Myo-inositol is an isomer of glucose that is a precursor in the phosphatidylinositol (PIP) cycle, a source of two second messengers: diacylglycerol (DAG) and inositol triphosphate (IP3). Clinical studies have reported that inositol is effective in relieving symptoms of depression. OBJECTIVE: The present study examined the effects of inositol on two animal models of depression: the Porsolt forced swim test, a behaviorally based model; and the reserpine-induced immobility model, a pharmacologically based model. METHODS AND RESULTS: Chronic inositol injections (daily for 14 days) of 1.2 g/kg (but not at lower doses) reduced immobility time and increased struggle time in the Porsolt test compared with control animals. The same dose and treatment schedule also reduced complete immobility time but did not affect ambulatory activity in the reserpine test compared with controls. Chronic oral treatment with inositol (10% in food for 14 days) had effects similar to IP inositol in the Porsolt test. CONCLUSIONS: The effect of inositol in animal models of depression supports its possible importance as a new treatment for the disorder, and permits research on its mechanisms of action.

Bipolar disorders
Inositol depletion
Lithium prophylaxis
Is epi-inositol anxiolytic?
Inositol and bipolar disorder
Inositol as an antidepressant

and further reading

Future Opioids
BLTC Research
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family