Contribution of GABA(A) and GABA(B) receptors to the discriminative stimulus produced by gamma-hydroxybutyric acid
by
Lobina C, Agabio R, Reali R, Gessa GL, Colombo G.
Bernard B. Brodie Department of Neuroscience,
Cagliari, Italy.
Pharmacol Biochem Behav 1999 Oct;64(2):363-5


ABSTRACT

The present study examined the involvement of GABA(A) and GABA(B) receptors in the discriminative stimulus effects of gamma-hydroxybutyric acid (GHB). Rats were trained to discriminate either 300 or 700 mg/kg GHB IG from water using a T-maze, food-reinforced drug-discrimination procedure. The direct GABA(B) agonist, baclofen, substituted completely for both training doses of GHB; its potency to substitute for GHB increased moderately as the training dose of GHB was increased. The positive GABA(A) modulator, diazepam, substituted partially for 300 mg/kg GHB, but failed to elicit GHB-appropriate responding in rats trained with the higher GHB dose. Finally, the GABA(B) antagonist, CGP 35348, completely blocked the discriminative stimulus effects of the high training dose of GHB, but only partially antagonized the effects of the low training dose. These results suggest that (a) GHB produces a compound stimulus, and (b) both GABA(B)- and GABA(A)-mediated cues are prominent components of this compound stimulus; the contribution of each component, however, appears to vary as the training dose of GHB is increased.
GHB
GABA
MDMA
Opioids
Reward
Alcohol
Phenibut
Dopamine
GHB: structure
GHB withdrawal
A GHB receptor?
GABAergic drugs
GHB and cocaine
Drugs and reward
GHB and the brain
GHB and alcoholism
GHB and narcolepsy
Narcolepsy: a review
Withdrawal syndrome
Fasting, euphoria and GHB
Gamma-hydroxybutyrate (GHB)


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