Psychoneuroendocrinology of depression.
Growth hormone

by
Dinan TG
Department of Psychiatry,
Royal College of Surgeons, Dublin, Ireland.
Psychiatr Clin North Am 1998 Jun; 21(2):325-39


ABSTRACT

The release of growth hormone (GH) from the anterior pituitary is regulated by hypothalamic peptides especially GH-releasing hormone (GHRH) and somatostatin, which in turn are controlled by classic neurotransmitters such as noradrenaline, dopamine, and acetylcholine, as well as negative feedback from GH and insulin-like growth factor-1. There has been extensive investigation of this axis in patients with depression. The most consistently reported abnormality is in noradrenergic-mediated GH release, which probably occurs via GHRH containing neurones. ACh-induced GH release through the somatostatin system, GABA, and also GHRH-stimulated release are reported as abnormal by some researchers.
GABA
Options
Dopamine
GH and GHB
Somatostatin
Acetylcholine
Noradrenaline
Antidepressants
GH and quality of life


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