Don't worry 'B' happy!: a role for GABA(B) receptors
in anxiety and depression

by
Cryan JF, Kaupmann K.
Neuroscience Research,
Novartis Institutes for BioMedical Research,
Novartis Pharma AG, Basel, Switzerland.
john_f.cryan@pharma.novartis.com
Trends Pharmacol Sci. 2005 Jan;26(1):36-43.


ABSTRACT

GABA, the main inhibitory neurotransmitter in the brain, regulates many physiological and psychological processes. Thus, dysfunction of the GABA system is implicated in the pathophysiology of several neuropsychiatric disorders, including anxiety and depression. However, the role of GABA(B) receptors in behavioural processes related to these disorders has not been resolved. GABA(B) receptors are G-protein-coupled receptors that function as heterodimers of GABA(B(1)) and GABA(B(2)) subunits. In addition to highly selective agonists and antagonists, novel GABA(B) receptor tools have been developed recently to further assist elucidation of the role of GABA(B) receptors in CNS function. These include mice that lack functional GABA(B) receptors, and novel positive modulators of the GABA(B) receptor. In this review, we discuss evidence that points to a role of GABA(B) receptors in anxiety and depression.
PTZ
Ethanol
Indiplon
GABA(B)
GABA(C)
Sedatives
L-838,417
Benzo choices
Anticonvulsants
GABAergic drugs
Benzodiazepines
Neuroactive steroids
GABA(A) and fluoxetine
Anxiolytics and antidepressants
GABA, pain and the cerebral cortex
Alpha 1 and alpha 2 GABA(A) receptor subunits
The alpha 2/alpha 3-subtypes of GABA(A) receptor


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