Acute and chronic fluoxetine treatment decreases
the sensitivity of rats to rewarding brain stimulation

by
Lee K, Kornetsky C
Boston University School of Medicine,
Department of Pharmacology,
MA 02118, USA.
Pharmacol Biochem Behav 1998 Jun; 60(2):539-44


ABSTRACT

The effects of fluoxetine on rewarding brain stimulation were determined in eight Wistar rats using a rate-independent discrete-trial threshold measure. Rats were implanted with bipolar, stainless steel electrodes either into the ventral tegmental area (VTA) or medial forebrain bundle (MFB). Acute administration of fluoxetine significantly raised the reward threshold (decreased sensitivity) at doses of 2.5, 5.0, 10.0, and 20.0 mg/kg, i.p., without altering latency of response. There were no significant differences between VTA and MFB groups. To determine the effects of chronic treatment, daily injections of 5.0 mg/kg fluoxetine were administered to rats for 21 days. Chronic treatment of fluoxetine continued to significantly elevate reward thresholds with no evidence of tolerance. The results of these experiments suggest that fluoxetine does not possess abuse potential and that serotonin produces an inhibitory effect on the mesolimbic dopaminergic reward system. Furthermore, these results suggest that the antidepressant effects of fluoxetine are not the direct result of excitation of brain reward systems, at least in the same manner as abused substances, for example, cocaine.
SSRIs
Dosage
Anxiety
Dopamine
Bupropion
Amineptine
Anhedonia
Nomifensine
Hypersomnia
Noradrenaline
Methylphenidate
Tranylcypromine
Prozac as a painkiller
Fluoxetine and cocaine
Imipramine v fluoxetine
Fluoxetine: 10th anniversary
Anhedonia and retarded depressives
Fluoxetine and corticosteroid receptors
Fluoxetine: norepinephrine, dopamine and 5-HT2c


Refs
and further reading

HOME
HedWeb
Nootropics
erythroxylum-coca.com
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family