Dopaminergic and serotonergic
properties of fluoxetine

Simon B, Appel JB
Department of Psychology,
University of South Carolina,
Columbia, USA.
Prog Neuropsychopharmacol Biol Psychiatry 1997 Jan; 21(1):169-81


1. Rats were trained to discriminate i.p. injections of a 5-HT agonist, LSD (0.08 mg/kg, n = 12) or a DA agonist, cocaine (10 mg/kg; n = 16) in a two lever, drug discrimination situation. 2. Animals were tested with fluoxetine (0.625-10 mg/kg) alone and in combination with low doses of the training drugs. 3. Fluoxetine did not substitute for either LSD or cocaine at any dose tested. A relatively low dose of fluoxetine (2.5 mg/kg) potentiated the discriminability of cocaine (2.5 mg/kg) from saline. A higher dose of fluoxetine (5.0 mg/kg) significantly enhanced the effects of a low dose of LSD (0.02 mg/kg), but only to 41.7% responses on the LSD-appropriate lever. 4. The data suggest that fluoxetine alters the discriminative stimulus properties of cocaine to a greater extent than those of LSD. 5. The ability of fluoxetine to potentiate the cocaine cue (but not to substitute for cocaine) suggests that both of those drugs affect DA systems, but do so through different mechanisms. For example, fluoxetine may not inhibit DA reuptake (to the same extent as cocaine), but may have other dopaminergic actions such as increasing DA receptor density.
SSRIs and sex
Partial responders
Fluoxetine and LSD
Fluoxetine and PMT
Fluoxetine and MDMA
Fluoxetine and MAO-A
Fluoxetine and MAO-B
Fluoxetine and weight
Fluoxetine and cocaine
Fluoxetine and bipolars
Fluoxetine and GABA(A)
Fluoxetine and oxytocin
Fluoxetine : side-effects
Antidepressant mechanisms
Comparisons and metabolites
Fluoxetine (Prozac) and new brain cells
Fluoxetine: norepinephrine, dopamine and 5-HT2c

and further reading

Future Opioids
BLTC Research
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family