Hormonal and temperature responses to the 5-HT(1A)
receptor agonist flesinoxan in normal volunteers

by
Pitchot W, Wauthy J, Hansenne M,
Pinto E, Fuchs S, Reggers J, Legros JJ, Ansseau M.
Psychiatric Unit, CHU Sart Tilman,
4000 Liege, Belgium,
wpitchot@chu.ulg.ac.be
Psychopharmacology (Berl) 2002 Oct;164(1):27-32


ABSTRACT

RATIONALE. Flesinoxan is a highly potent and selective 5-HT(1A) agonist and appears to be a potentially interesting neuroendocrine serotonergic probe. OBJECTIVES. We assessed hormonal (ACTH, cortisol, prolactin and growth hormone) and temperature responses to flesinoxan in normal volunteers. METHODS. In a double-blind placebo-controlled study, single doses of 0.5 mg and 1 mg were injected over 10 min into 12 healthy male volunteers at 1-week intervals. Temperature and hormonal responses were measured at times -30, 0, 15, 30, 60, 90, and 120 min. RESULTS. Flesinoxan induced a significant and dose-dependent increase in adrenocorticotropic hormone (ACTH), cortisol, prolactin (PRL), growth hormone (GH) and a decrease in body temperature. Tolerance to flesinoxan was excellent. CONCLUSIONS. These results showed the role of 5-HT(1A) mechanisms in the PRL, ACTH, cortisol, GH, and temperature responses to flesinoxan. In the present study, flesinoxan appears a very promising serotonergic neuroendocrine probe.
SSRIs
5-HT2
5-HT3
5-HT1
5-HT1b
5-HT1a
Buspirone
Alprazolam
Flesinoxan
Knockout mice
5-HT1a v 5-HT1b
5HT1A and F11440


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